Optimization of Zika DNA vaccine by delivery systems

DNA Vaccine Administration Through Transdermal Delivery Systems

Infectious disease is a global problem and it effects almost all sections of peoples. A number of microorganisms are available to cause a variety of diseases. The infectious disease has tremendous impact on human health which has made the life miserable. The basic treatment for the infectious disese is the use of antimicrobials and the use of vaccination. Both of the above methods have the side...

Intradermal vaccine delivery: will new delivery systems transform vaccine administration?

There has been a recent resurgence of interest in intradermal vaccine delivery. The physiological advantages of intradermal vaccine delivery have been known for some time, but the difficulties associated with performing an intradermal injection have historically limited its use. New delivery systems currently in development facilitate convenient intradermal vaccination, unlocking the potential ...

ZIKA-001: Safety and Immunogenicity of an Engineered DNA Vaccine Against ZIKA virus infection

Use of bacteria in DNA vaccine delivery

Vanessa Bastos Pereira; Marcela Santiago Pacheco Azevedo; Tessália Diniz Luerce Saraiva; Bianca Mendes Souza; Meritxell Zurita Turk; Camila Prósperi De Castro; Pamela Mancha Agresti; Fernanda Alvarenga Lima; Vasco Azevedo; Daniela Santos Pontes and Anderson Miyoshi Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Ho...

Increased DNA vaccine delivery and immunogenicity by electroporation in vivo.

DNA vaccines have been demonstrated to be potent in small animals but are less effective in primates. One limiting factor may be inefficient uptake of DNA by cells in situ. In this study, we evaluated whether cellular uptake of DNA was a significant barrier to efficient transfection in vivo and subsequent induction of immune responses. For this purpose, we used the technique of electroporation ...